Molecular Biology Lab
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  Department of Biotechnology, Government of India provided a grant support to Institute of Bioinformatics and NIMHANS to carry out proteomic investigation to analyze neurological diseases.
  IOB is recognized as a research center for award of Ph.D. degrees with Manipal University.


The Team



Research Lab


Tissue culture




Triage test to diagnose presumptive pulmonary tuberculosis: Scientists at IOB have written an expert commentary based on extensive research from published data, which emphasizes the need for incorporating a triage test to diagnose presumptive tuberculosis, aiming to stop ongoing transmission and reduce the TB burden. The commentary has been published in The Lancet Global Health.

Identification of predictive biomarkers for COVID-19 severity: By employing an integrative multi-omics approach, a team of scientists at IOB and Pandey lab have identified a set of biomarkers which can be exploited to predict a more severe course in clinical COVID-19 outcomes. The findings are published in The Lancet Digital Health.

Interactome of SARS-CoV-2 proteins and human ion channels: Using machine learning based approaches protein-protein interactions between human ion-channels and SARS-CoV-2 proteins were predicted and the host pathways involving these interactions were studied by a team of scientists at IOB. The findings of the study are published in the journal Pathogens.

Profiling of glycopeptides of chondroitin sulfate proteoglycans: Scientists from IOB have developed a method to characterize chondroitin sulfate proteoglycan (CSPG) using mass spectrometry. The study carried out is published in the journal Journal of Proteins and Proteomics.

Pan-cancer quantitation of epithelial-mesenchymal transition dynamics using targeted proteomics approach for advancing novel therapeutics: Scientists from IOB have developed a parallel reaction monitoring-based targeted proteomics method for quantifying abundances of EMT-associated proteins across cancer cell lines. The results from the above study were published in Journal of Translational Medicine.

Identification of Proteomic Signatures in Diffuse and Intestinal Subtypes of Gastric Cancer: IOB scientists designed a study to identify the differences between diffuse and intestinal subtypes of gastric cancer at the protein level using high-resolution mass spectrometry. The findings of the study was published in Cancers.

Alterations in ion channels interacting with lipid metabolism and epithelial-mesenchymal transition in esophageal squamous cell carcinoma: By employing computational approaches, a team of IOB scientists designed a study to identify aberrations in ion channels interacting with lipid metabolism and epithelial to mesenchymal transition in esophageal squamous cell carcinoma. The findings of the study are published in the journal Frontiers in Molecular Biosciences.


IOB mapped the human proteome for the first time:
Researchers from the Institute of Bioinformatics, Bangalore, as part of a 72-member team, have for the first time deciphered a near complete protein map of human beings. Results from this landmark study is featured on the cover of the prestigious journal Nature  
NDTV coverage on the Human Proteome Map

Click here to view more news articles on Human Proteome Map

IOB's contribution to the India's Research Landscape:
The Department of Science and Technology (DST), Government of India published "India's Research Landscape: Output, Collaboration and Comparative Performance - Bibliometric Studies" on February 17, 2016, which consisted of two reports. First report compiled by Thomson Reuters and entitled "India's Research Output and Collaboration (2005-14): A Bibliometric Study" while the other report was independently compiled by Elsevier and entitled "International Comparative Performance of India's Research Base (2009-14)." In Thomson Reuters report "Human Protein Reference Database" paper published in the year 2009 is ranked second among the Top 10 Publications with Indian Affiliation in the area of Biology and Biochemistry and "A draft map of human proteome" featured on the cover of Nature in 2014, was found to be cited more than 400 times within a short span and is ranked sixth.

In Elsevier report Human Protein Reference Database" is ranked second in the area of Biochemistry, Genetics and Molecular Biology with 1,029 citations.

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