| Whole Genome Scale Expression Profiling of Human Temporal Lobe Epilepsy
Epilepsy is a common chronic neurological condition which is characterized by recurrent unprovoked epileptic seizures. These seizures are transient signs and/or symptoms due to abnormal, excessive or synchronous neuronal activity in the brain. It affects approximately 50 million people worldwide. Among the different forms of epilepsy, temporal lobe epilepsy (TLE) has a special importance as it is the most common but the difficult one to treat epileptic syndromes in adults. Understanding the cellular (neuronal) and brain processes responsible for individual seizure types and epileptic disorders will lead to new approaches to prevention, treatment and care. Taking these things into consideration we intended to delineate genomic profile of medial temporal lobe epilepsy (MTLE) by genome wide scanning of gene expression levels leading to the discovery of the biomarkers and also to find new molecules as a target of therapy for MTLE.
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