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: IOB Scientists have developed database of Primary Immunodeficiency Disease genes known as 'Resource of Asian Primary Immunodeficiency Disease (RAPID)' in collabration with RIKEN, Japan. We have also developed algorithm for the prediction of candidate primary Immunodeficiency disease genes using support vector machine learning approach Results of these studies have been published in 'Nucleic Acids Research' and 'DNA Research' respectively.
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Molecular profiling of Embryonic Stem Cells and Embryonic Carcinoma Cells: Scientists from IOB and Pandey lab have identified key molecules that differentiate embryonic stem cells from embryonic carcinoma cells by quantitative proteomics. The findings from the above study was published in the journal Proteomics.
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Investigation of Molecular Markers of Neuronal Differentiation: Using advanced labeling technology, molecular markers of differentiation of motor neurons and astrocytes from embryonic stem cells were identified in a collaborative study between IOB, Pandey lab and Institute of Cell Engineering, Johns Hopkins University Findings from this study are published in Journal of Proteome Research.
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Quantitative Proteomic Investigation of Hepatocellular Carcinoma: IOB scientists unveil the first large scale quantitative proteomic profiling of hepatocellular carcinoma using robust discovery platforms such as iTRAQ labeling and high resolution mass spectrometry. The study revealed several novel and known upregulated proteins as potential biomarkers in hepatocellular carcinoma and results are published Journal of Proteome Research.
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Gene expression studies in Esophageal Squamous Cell Carcinoma: Scientists at IOB used a combination of DNA microarrays and immunohistochemical labeling of tissue microarrays to delineate gene expression patterns in cancer of esophagus and subsequently to validate molecular signatures specific to this cancer. Results of this investigation are published in Cancer Biology and Therapy.
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IOB scientists create the largest community resource of experimental data in human proteins.
It is a portal for sharing and integration of human protein data.
The international collaborative work is published in February issue of .
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The 'circuitry' in human cells was
analyzed by IOB scientists and published in .
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: IOB has successfully completed
analysis of the human X chromosome. This work was published
in and recently covered in a story
in
Highlights of this study included discovery of dozens of novel
genes using comparative genomics and experimental validation.
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, a first of its kind database that is
a comprehensive resource for all human plasma proteins along
with their isoforms. This database was featured
on the cover of the journal
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Two of the databases developed
by our Institute, and
were covered by the journal
as databases of special interest. Other news articles have
also appeared which cover ongoing projects in IOB.
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represents a centralized platform to visually depict and integrate
information pertaining to domain architecture, post-translational modifications, interaction networks and disease associations for each protein in the human proteome.
This database has been published in
, and .
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is a database for accessing cancer microarray studies to identify
characteristic cancer signatures. Oncomine was developed jointly
by IOB and the Chinnaiyan Lab at the University of Michigan.
This database has been published in
and .
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Analysis of protein tyrosine phosphatases encoded by the human genome was carried out using computational biology and experimental methods.
The IOB study identified novel members of the tyrosine phosphatases family and novel transcript variants. Experimentally validation was done using RT-PCR and Northern blot analysis.
This study was published in and the analysis is available at
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was carried out collaboratively
by scientists at IOB and at Johns Hopkins University.
These studies were published in , and ,
respectively.
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Protein-Protein interaction data in HPRD is made available
in Proteomics Standards Initiative - Molecular interaction
(PSI- MI) format which defines community standards for data
representation in proteomics and facilitates data comparision,
exchange and verification. The article has
been published in
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Elsevier, a world-leading provider of scientific, technical and medical information
products
and services, has launched its second global CodeForScience (CFS) competition.
Institute
of Bioinformatics is one of the key support member to promote the event.
CodeForScience is a global series of application development competitions for
scientists,
researchers and developers. The CodeForScience India competition is co-sponsored
by global
technology companies, NVIDIA, Thermo Scientific, and Microsoft Research.
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An article that appeared in The Hindu covered a new collaboration planned
between Madurai Kamaraj University and the Institute of Bioinformatics.
MKU is going to sign an MoU with IOB for exploring training and research
collaboration in the field of bioinformatics, genomics, transcriptomics
and proteomics between the two leading institutions.
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Our publication on urinary proteome "A comprehensive map of the human urinary proteome" has been cited as one of the most read articles in the Journal of Proteome Research
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Nature India, in its July 2011 issue, under 'Science news' section, has featured the study on Human Urinary Proteome published in Journal of Proteome Research (June 2011) by IOB in collaboration with Pandey Lab at JHU.
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Proteomic Progress : Cell Press has recently highlighted research achievements of IOB in its 'Chemistry and Biology Innovations' section. The article narrates the transformation of IOB from a small research centre dedicated to biological databases into a multifaceted research institute well equipped to carry out Proteogenomic analyses of large number of organisms which are relevant to global as well as Indian perspectives.
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Harsha Gowda, a research scientist |
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at IOB has received a Wellcome Trust-DBT Early Career Fellowship which is intended for the most promising young researchers in India.
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Dr. Akhilesh pandey was featured in Hopkins Medicine magazine as one of the visionary proteomics researchers working towards mapping the entire human proteome. The article also provides a glimpse of his journey and quest towards establishing a world class research center in India.
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IOB successfully hosted a two days Indo-Canandian collaborative workshop on "Integrative and Computa- tional Biology" on December 16 and 17. Dr. Brenda Andrews, Director, Donelly Center for Cellular and Biomolecular Research, University of Toronto led four member delegation from Canada in this workshop.
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Journal of Proteome Research, in its May 2006 issue, highlighted the
achievements of Akhilesh Pandey and co workers at IOB in India, JHU (USA) and University of Wurzburg (Germany) in successfully mapping and
assembling largest human interactome. |
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Science,
in its April 2006 issue, has covered Plasma Proteome Database. |
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Nature,
in its July 2005 issue, has covered India's biotech boom.
A special mention has been made, of the world class research
done by the Institute Of Bioinformatics, to characterize the
human X chromosome. |
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Nature
Genetics in its April 2005 edition came out with an editorial
,
which praised the Institute's efforts in annotating the
X chromosome. |
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